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Date Posted: Sun, Mar 14, 08:53:14am
Author: cheryl
Subject: Olive Leaf Extract

Has anyone ever heard or used Olive Leaf Extract? I saw something at Dana's site: www.danasview.net/myson.htm#viral2 and then looked it up and seems like quite a few people have had success with it so i was wondering if anyone here had used it...the first is information about it, the second mentions it only with other stuff but seemded to have good information even tho it appears "old".
Cheryl

Olive Leaf Extract
Julie Roach and Julie Kreloff, M.S., R.D.
http://www.forhealthsolutions.net/olive-leaf.html
The olive tree has been studied for centuries, and over the years many medicinal benefits have been attributed to it. Olive oil, buds, leaves, and roots have all been used medicinally, but olive leaf extract is of exceptional interest. A bitter substance in the extract was found and named oleuropein. Numerous studies have been conducted to determine the benefits of oleuropein. In 1962, an Italian researcher discovered that oleuropein lowered blood pressure in animals.[1] Other European researchers confirmed this finding. In addition, they found it could also increase blood flow in the coronary arteries [2], relieve arrhythmias, and prevent intestinal muscle spasms. In 1969, a Dutch researcher determined the active ingredient in oleuropein to be a substance called elenolic acid. Elenolic acid was found to have powerful anti-bacterial properties. [3] By the late 1960's, research by scientists at Upjohn showed that elenolic acid also slowed the growth of viruses. It was found to inhibit a variety of viruses associated with the common cold in humans. Further, a number of research studies at this time showed that calcium elenolate, a salt of elenolic acid, had a strong effect not just on viruses, but bacteria and parasitic protozoans as well. [4] Olive leaf extract has been found to be an extremely effective anti-viral, anti-retroviral, and bactericidal substance. Research suggests that a number of mechanisms are involved. These mechanisms include:
· A critical interference with certain amino acids that are essential for the vitality of viruses.
· Interference with the viral infection and/or the spread of the virus by inactivation, or by preventing virus shedding, budding or assembly at the cell membrane.
· The ability to directly penetrate infected host cells and inhibit viral replication.
· In the case of retro viruses, it neutralizes the production of reverse transcriptase and protease.
· Stimulates phagocytosis (the process of engulfment and destruction of particulate matter by phagocytic cells such amacrophages and neutrophils).

Due to olive leaf's anti-viral properties, it has been found to be beneficial in the treatment of conditions caused by, or associated with a virus, retrovirus, bacterium, or protozoan. Such conditions include influenza, the common cold, meningitis, Epstein-Barr Virus (EBV), encephalitis, herpes I and II, human herpes virus 6 and 7, shingles, HIV/ARC/AIDS, chronic fatigue, hepatitis B, pneumonia, tuberculosis, gonorrhea, malaria, dengue, bacteremia, severe diarrhea, blood poisoning, and dental, ear, urinary tract and surgical infections.

Recent studies have also shown that olive leaves, when stored in closed plastic bags at a specific temperature and for a designated time, were found to have increased antioxidant levels. The antioxidant that can be isolated is called 3,4-dihydroxyphenylethy 4-formyl-3-formylmethyl-4-hexenoate (3,4-DHPEA-EDA).[5] This antioxidant is comparable to alpha-tocopherol (Vitamin E). Phenolated compounds have also been found in the olive leaf and bud. These compounds include oleuropein and flavonoids such as rutin flavonol.[6] These are both potent antioxidant compounds. Flavonoids inhibit LDL oxidation[7] and oleuropein has antimicrobial properties.

For some very sick people, including those with chronic fatigue syndrome or those who have particularly large amounts of viruses or bacteria in their bodies, olive leaf extract may generate detoxification symptoms. These symptoms are known as the "die-off effect". Such individuals may actually feel worse for a short time before feeling better. The "die-off effect," or Herxheimer Reaction, refers to symptoms generated by the detoxification process.

Detoxification symptoms may be noticed immediately after starting the olive leaf extract supplement. Reactions include extreme fatigue, diarrhea, headaches, muscle/joint achiness or flu-like symptoms. In the case of severe detoxification symptoms, the number of capsules can be reduced or possibly eliminated. The body may then need up to a week to complete the "die-off" process. Once the symptoms have improved, the supplement can be resumed at a lower dosage and then increased slowly. Research indicates that doses many times higher than recommended are not likely to produce toxic or other side effects. [8]

Researchers are now trying to see if olive leaf extract can benefit AIDS patients. Research shows that it inhibits the production of both reverse transcriptase and protease, enzymes necessary for the survival of HIV. Fungal and yeast infections are included in the wide spectrum of conditions aided with olive leaf extract. It has been said that more than 10 million Americans have disfiguring fungal nail infections, a widely ignored medical problem. Fungal infections are frequently found among patients with AIDS, cancer and diabetes, athletes, the elderly, people who spend considerable time standing or who wear the same shoes day after day, or those who wear artificial fingernails. Drugs taken for cancer and AIDS lower resistance and are believed to make people more susceptible to fungal infections. Olive leaf extract may offer a natural and less expensive method of treatment for these infections.
References
1.Panizzi, L., The constitution of oleuropein, a bitter glucoside of the olive with hypotensive action. Gazz. Chim Ital, 1960. 90: p. 1449-85.
2. Zarzuelo, A., Vasodilator effect of olive leaf. Planta Med, 1991. 57(5): p. 417-9.
3. Fleming HP, W.W., Etchells JL, Isolation of a bacterial inhibitor from green olives. Appl Microbiol, 1969. 18: p. 856-860.
4. Renis, H., In vitro antiviral activity of calcium elenolate. Antimicrob Agents Chemother, 1969: p. 167-172.
5. Paiva-martins, F., Isolation and characterization of the anitoxidant component 3,4-dihydroxyphenylethyl 4-formyl-3- formylmethyl-4 hexenoate form olive leaves. J Agric Food Chem, 2001. 49(9): p. 4214-9.
6. Hertog, M., et al, Dietary antioxidant flavonoids and risk of coronary heart disease: Zutphen Elderly Study. Lancet, 1993. 342: p. 1007-11.
7. Visioli F, G.C., Oleuropein protects low density lipoprotein from oxidation. Life Sci, 1994. 55(24): p. 1965-1971
8. Elliot, G., et al, Preliminary safety studies with calcium elenoate, an antiviral agent. Antimicrob Agents Chemother, 1969: p. 173.
How To Take Olive Leaf Extract
Olive leaf extract is currently available in the form of 500mg. capsules. The routine dosage is one tablet every six hours. The supplement should be taken between meals for best results. In the case of bad colds or flu, the dosage may be increase to two capsules every six hours.
For acute infections, some individuals have taken more -- three or four every six hours -- and reported rapid relief. If a "die-off effect" occurs, the number of capsules can be decreased or temporarily discontinued.
For healthy individuals seeking more energy or the preventative benefits of olive leaf extract, one or two tablets a day is suggested.
http://www.allergyconnection.com/autism.html
Studies have shown that over 550,000 children in the United States have been diagnosed with Autism Spectrum Disorder.
In 1997, "Pedriatric News", a conventional pediatric magazine mailed monthly to primary care pediatricians stated that there was a 100% increase in the diagnosis of Autism from 1990 to 1995. As of 1997, the significant increase was attributed to physicians being more aware of making the proper diagnosis.
"AMA News" reported that the diagnosis of Autism, ADHD and Learning Disorders had increased 20% over the previous eleven years. The California Department of Scientists reported that in the last eleven years, there was a 273% increase in the diagnosis of Autism and close to a 2000% increase in the diagnosis of ADHD, Learning Disorders and Autism.
It is now becoming quite obvious even to medical experts that the rate of Autism has dramatically escalated in the 1990s.
It is my opinion that there are two subsets of Autism. The first, which would not account for a dramatic increase, is children who are destined to have Autism at birth, a "metabolic/genetic problem." To account for the dramatic increase in the diagnosis of Autism, a significant number of children appear to have Autism caused by an immune system stressor. Environmental pollution, (especially pesticides), immunization reactions, diet (especially starting cow's milk at approximately one year of age), frequent use of antibiotics to treat Otitis Media during the 1-1/2 years of life appear to be significant risk factors.
In general, children with the "genetic/metabolic type" who have delayed development before 12 months have a more ominous prognosis. In contrast, children with the later onset, who are noted to have normal development followed by regression of speech, cognitive skills, and social skills after one year of age often have a much better prognosis.
In general, the earlier the diagnosis is made with medical intervention, the better the prognosis.
A common medical history is a child with an increase in ear infections requiring multiple courses of antibiotics who has been started on cow's milk by one year of age. There is often a positive allergy history with multiple complaints--eye, ear, nose and respiratory allergy, gastrointestinal complaints (abdominal pain, limited appetite), increased food cravings (especially milk, wheat, and sugar), urinary symptoms (frequency), muscle and joint pain, and of most significance the central nervous system. Often there is a regression in speech, cognitive and social skills. Children with this profile usually by 18-30 months of age receive a diagnosis of Autism Spectrum Disorder.
In recent years a growing number of parents point at the MMR vaccine as the root cause of Autism. For at least the past 10-15 years young children have been receiving many combined vaccines before age two. This includes 3 Hepatitis B, 4 DPT, 4 Polio, 3 HIB, Chickenpox and the MMR vaccines by age two. By the time the MMR is given at approximate 15 months, most children have already received at least 10 immunizations. Perhaps a child's immune system is not ready at 15 months of age.
Most, if not all, autistic children have sensory integration issues with hypersensitivity to sound, touch, taste, pain and/or a vestibular proprioceptive component. These children are also susceptible to environmental chemical insult, especially pesticides and food preservatives. I have yet to see a child with Autism Spectrum Disorder who did not have sensory modulation issues. The most prominent is sensitivity to sound as many children with Autism hold their ears. One should look for Auditory Processing Disorder as a primary component in the diagnosis of Autism Spectrum Disorder.
Dysbiosis/Leaky Gut Syndrome
A Leaky Gut manifests as an imbalance between bacteria and yeast. Leaky gut is caused primarily by the increased use of antibiotics leading to increased intestinal permeability. With increased GI permeability after antibiotics, good bacteria such as Lactobacilli are destroyed whereas the Candida (yeast) is not affected by antibiotics. Thus the integrity of the gut wall membrane is adversely affected leading to an imbalance of good and bad bacteria. This allows nutrients and toxins to leak through the GI wall. The consequence is a dysregulated immune system that often results in behavior, development and learning abnormalities. Antibiotics, casein/gluten products, and sugar appear to be the leading causes of Leaky Gut Syndrome. Patients having Leaky Gut and allergies often have other hypersensitivities including dust, pollen, additives and environmental chemicals.
Casein/Gluten-free diet
Children with Autism very often with ingestion of casein/gluten related foods incompletely digest these foods and develop gluten/casein peptides called Gluteomorphine and Caseomorphine. These peptides are partially digested and appear to react with opioid receptors in the brain. This reaction mimics opiate drugs such as heroin and morphine. The temporal lobe, the center for language and social skills, is often involved with developmental delay. Children with Autism especially with a positive history of antibiotic use should go on a casein and/or gluten-free diet. This means the elimination of all milk products, (cow's milk, cheese yogurt and ice cream) as well as gluten products (wheat, oat, barley and rye).
Other children respond to limiting sugar, milk products, baked goods, junk food, craved food, preservatives, and artificial flavorings. Supplements to consider include B6, magnesium, calcium, DMG, Super Nuthera, Amino Acids, Antioxidants (Beta Carotene, Vitamins C and E, Selenium), Phosphatidyl Serine, Piracetam, Digestive Enzymes, L-Glutathione, CoQ10, Ginkgo, Essential Fatty Acids (especially Omega 3), Folic acid, Biotin, Inositol, B Vitamins (B6 as well as B1, 2, 3, 5, 12) and Vitamin D.
An anti-candida program should include probiotics to control bacteria and yeast imbalance in the GI tract by competing with candida for sugar. This includes FOS (fructooligusaccharides) to promote the growth of good bacteria. A probiotic should contain Lactobacillus, Bifidus and FOS). Other supplements to control yeast include garlic, grapeseed extract, caprylic acid, Pau D'Arco tea, Olive Leaf Extract, Oil of Oregano, MCT oil and Candicin.
Regarding antifungal medications to control yeast, Nystatin should be considered first since this medication is nontoxic, stays in the gut, is not absorbed in the blood and does not adversely affect the liver. Unfortunately, over the past ten years there has been an increase in candida resistant strains to Nystatin.
Of Diflucan, Nizoral, Sporanox and Lamisil, I personally prefer Diflucan at a dosage of approximately three milligrams per kilogram. If this medication is used three months or longer, liver function tests must be checked to be certain Diflucan is not adversely affecting the liver. Nizoral, Sporanox, Lamisil would also require liver function tests every three months.
Therapies: Speech therapy, occupational therapy and approximate school placement remain priorities. Other medical approaches to consider include:
ABA program - (LoVaas)
Auditory Integration Training - Berrard, Tomatis, Semores
Sensory Integration Program
Homeopathy
Herbal Therapy
Medications:
Some children with Autism Spectrum Disorder require medication: Physicians should consider the following meds:
Low dose Prozac starting with 1 milligram and gradually increasing 1 milligram every two weeks to a maximum of five milligrams. Prozac may help attention, focus, as well as obsessive/compulsive behavior. However, if the dosage of 5 milligrams is exceeded, children are more likely to be hyperactive and have insomnia.
The second medication I strongly consider is Tenex which is primarily considered an antihypertensive or a second line medication for ADHD. Tenex is an excellent mood stabilizer and often has a calming effect for autistic children.
Risperdal, which is considered to be an antipsychotic is receiving more and more usage because of its positive benefits for children with Autism. This medication does have a number of side effects, but far fewer than medications in the same family classification--Haldol and Zyprexa. Currently, double-blind control studies are being carried out in several research centers around the country for the use of Risperdal in Autism.
Antiviral medications such as Acyclovir (Zovirax) or Amantadine have been advocated by several medical experts.
Naltrexone is available from a compounding pharmacist at a dose of three milligrams per day. Naltrexone has an anti-opioid effect.
Intravenous Gamma Globulin based on the studies of Dr. Gupta appears to be helping a number of children with Autism. If interested in this treatment, I recommend looking at the Good News Doctor website. Dr. Jeff Bradstreet in Florida is providing IVIG and appears to be having success.
Prednisone which has been studied at Jefferson Medical School, is still favored by many pediatricians and neurologists.
Lab Tests
Lab tests to consider include the following:
DAN Protocol to assess metabolic immune system defects.
Organic acid testing by Dr. William Shaw. The urine organic acid tests provides a metabolic marker for increased fungal metabolites in the urine. Elevated arabinose and tartaric acid can be helpful in diagnosing a yeast problem. An increased DHPPA level indicates anaerobic organisms and can be treated with a medication such as Metronidazole (Flagyl) or a supplement called Culturelle (Lactobacillus GG).
Comprehensive Digestive Stool Analysis (CDSA) from the Great Smokies Lab.
Spect Scan can document decreased blood flow to the temporal lobe. The temporal lobe is the center for language and social skills.
Casein/gluten antibodies serum and urine. I prefer the casein/gluten blood test to the urine IgA & IgG as I am finding more positive results with the blood test. With Autism, I would prefer to overdiagnose casein/gluten than overlook this problem.
Personally I often order the CDSA, (comprehensive digestive stool analysis) and casein/gluten antibodies. For children receiving Secretin IV, I order secretin antibody levels.
Books:
The books I recommend include the following:
Biologic Treatments for Autism PDD by William Shaw, Ph.D. This in my opinion is the best single book on Autism.
Special Kids, Special Diets by Lisa Lewis. This book provides excellent information for the casein and/or gluten-free diet.
Is This Your Child? by Doris Rapp, M.D. Although Dr. Rapp's book focuses on the allergy/behavior/recurrent infection connection, it can certainly help the child with Autism as many as these children have significant behavior issues.
Healing Childhood Ear Infections by Michael Schmidt, Ph.D. Dr. Schmidt's book has a wealth of material on herbal/homeopathic treatments.
The Out of Sync Child by Carol Kranowitz. This is an excellent book on the sensory integration issue which impacts most, if not all, children with autism.
To summarize, there certainly appears to be a connection between the gastrointestinal tract immune system and central nervous system. Leaky gut and food allergies/hypersensitivities appear to have an adverse impact on the temporal lobe--the speech and language center for the brain.

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Re: Olive Leaf Extract -- lg, Tue, Mar 23, 11:27:00pm
Re: Olive Leaf Extract -- Vince, Wed, Jun 02, 05:50:05pm
- Re: Olive Leaf Extract -- cheryl, Tue, Dec 07, 12:47:03am

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>Has anyone ever heard or used Olive Leaf Extract? I >saw something at Dana's site: >www.danasview.net/myson.htm#viral2 and then looked it >up and seems like quite a few people have had success >with it so i was wondering if anyone here had used >it...the first is information about it, the second >mentions it only with other stuff but seemded to have >good information even tho it appears "old". >Cheryl > >Olive Leaf Extract >Julie Roach and Julie Kreloff, M.S., R.D. >http://www.forhealthsolutions.net/olive-leaf.html >The olive tree has been studied for centuries, and >over the years many medicinal benefits have been >attributed to it. Olive oil, buds, leaves, and roots >have all been used medicinally, but olive leaf extract >is of exceptional interest. A bitter substance in the >extract was found and named oleuropein. Numerous >studies have been conducted to determine the benefits >of oleuropein. In 1962, an Italian researcher >discovered that oleuropein lowered blood pressure in >animals.[1] Other European researchers confirmed this >finding. In addition, they found it could also >increase blood flow in the coronary arteries [2], >relieve arrhythmias, and prevent intestinal muscle >spasms. In 1969, a Dutch researcher determined the >active ingredient in oleuropein to be a substance >called elenolic acid. Elenolic acid was found to have >powerful anti-bacterial properties. [3] By the late >1960's, research by scientists at Upjohn showed that >elenolic acid also slowed the growth of viruses. It >was found to inhibit a variety of viruses associated >with the common cold in humans. Further, a number of >research studies at this time showed that calcium >elenolate, a salt of elenolic acid, had a strong >effect not just on viruses, but bacteria and parasitic >protozoans as well. [4] Olive leaf extract has been >found to be an extremely effective anti-viral, >anti-retroviral, and bactericidal substance. Research >suggests that a number of mechanisms are involved. >These mechanisms include: >· A critical interference with certain amino acids >that are essential for the vitality of viruses. >· Interference with the viral infection and/or the >spread of the virus by inactivation, or by preventing >virus shedding, budding or assembly at the cell >membrane. >· The ability to directly penetrate infected host >cells and inhibit viral replication. >· In the case of retro viruses, it neutralizes the >production of reverse transcriptase and protease. >· Stimulates phagocytosis (the process of engulfment >and destruction of particulate matter by phagocytic >cells such amacrophages and neutrophils). > >Due to olive leaf's anti-viral properties, it has been >found to be beneficial in the treatment of conditions >caused by, or associated with a virus, retrovirus, >bacterium, or protozoan. Such conditions include >influenza, the common cold, meningitis, Epstein-Barr >Virus (EBV), encephalitis, herpes I and II, human >herpes virus 6 and 7, shingles, HIV/ARC/AIDS, chronic >fatigue, hepatitis B, pneumonia, tuberculosis, >gonorrhea, malaria, dengue, bacteremia, severe >diarrhea, blood poisoning, and dental, ear, urinary >tract and surgical infections. > >Recent studies have also shown that olive leaves, when >stored in closed plastic bags at a specific >temperature and for a designated time, were found to >have increased antioxidant levels. The antioxidant >that can be isolated is called 3,4-dihydroxyphenylethy >4-formyl-3-formylmethyl-4-hexenoate >(3,4-DHPEA-EDA).[5] This antioxidant is comparable to >alpha-tocopherol (Vitamin E). Phenolated compounds >have also been found in the olive leaf and bud. These >compounds include oleuropein and flavonoids such as >rutin flavonol.[6] These are both potent antioxidant >compounds. Flavonoids inhibit LDL oxidation[7] and >oleuropein has antimicrobial properties. > >For some very sick people, including those with >chronic fatigue syndrome or those who have >particularly large amounts of viruses or bacteria in >their bodies, olive leaf extract may generate >detoxification symptoms. These symptoms are known as >the "die-off effect". Such individuals may actually >feel worse for a short time before feeling better. The >"die-off effect," or Herxheimer Reaction, refers to >symptoms generated by the detoxification process. > >Detoxification symptoms may be noticed immediately >after starting the olive leaf extract supplement. >Reactions include extreme fatigue, diarrhea, >headaches, muscle/joint achiness or flu-like symptoms. >In the case of severe detoxification symptoms, the >number of capsules can be reduced or possibly >eliminated. The body may then need up to a week to >complete the "die-off" process. Once the symptoms have >improved, the supplement can be resumed at a lower >dosage and then increased slowly. Research indicates >that doses many times higher than recommended are not >likely to produce toxic or other side effects. [8] > >Researchers are now trying to see if olive leaf >extract can benefit AIDS patients. Research shows that >it inhibits the production of both reverse >transcriptase and protease, enzymes necessary for the >survival of HIV. Fungal and yeast infections are >included in the wide spectrum of conditions aided with >olive leaf extract. It has been said that more than 10 >million Americans have disfiguring fungal nail >infections, a widely ignored medical problem. Fungal >infections are frequently found among patients with >AIDS, cancer and diabetes, athletes, the elderly, >people who spend considerable time standing or who >wear the same shoes day after day, or those who wear >artificial fingernails. Drugs taken for cancer and >AIDS lower resistance and are believed to make people >more susceptible to fungal infections. Olive leaf >extract may offer a natural and less expensive method >of treatment for these infections. >References >1.Panizzi, L., The constitution of oleuropein, a >bitter glucoside of the olive with hypotensive action. >Gazz. Chim Ital, 1960. 90: p. 1449-85. >2. Zarzuelo, A., Vasodilator effect of olive leaf. >Planta Med, 1991. 57(5): p. 417-9. >3. Fleming HP, W.W., Etchells JL, Isolation of a >bacterial inhibitor from green olives. Appl Microbiol, >1969. 18: p. 856-860. >4. Renis, H., In vitro antiviral activity of calcium >elenolate. Antimicrob Agents Chemother, 1969: p. >167-172. >5. Paiva-martins, F., Isolation and characterization >of the anitoxidant component 3,4-dihydroxyphenylethyl >4-formyl-3- formylmethyl-4 hexenoate form olive >leaves. J Agric Food Chem, 2001. 49(9): p. 4214-9. >6. Hertog, M., et al, Dietary antioxidant flavonoids >and risk of coronary heart disease: Zutphen Elderly >Study. Lancet, 1993. 342: p. 1007-11. >7. Visioli F, G.C., Oleuropein protects low density >lipoprotein from oxidation. Life Sci, 1994. 55(24): p. >1965-1971 >8. Elliot, G., et al, Preliminary safety studies with >calcium elenoate, an antiviral agent. Antimicrob >Agents Chemother, 1969: p. 173. >How To Take Olive Leaf Extract >Olive leaf extract is currently available in the form >of 500mg. capsules. The routine dosage is one tablet >every six hours. The supplement should be taken >between meals for best results. In the case of bad >colds or flu, the dosage may be increase to two >capsules every six hours. >For acute infections, some individuals have taken more >-- three or four every six hours -- and reported rapid >relief. If a "die-off effect" occurs, the number of >capsules can be decreased or temporarily discontinued. >For healthy individuals seeking more energy or the >preventative benefits of olive leaf extract, one or >two tablets a day is suggested. >http://www.allergyconnection.com/autism.html >Studies have shown that over 550,000 children in the >United States have been diagnosed with Autism Spectrum >Disorder. >In 1997, "Pedriatric News", a conventional pediatric >magazine mailed monthly to primary care pediatricians >stated that there was a 100% increase in the diagnosis >of Autism from 1990 to 1995. As of 1997, the >significant increase was attributed to physicians >being more aware of making the proper diagnosis. >"AMA News" reported that the diagnosis of Autism, ADHD >and Learning Disorders had increased 20% over the >previous eleven years. The California Department of >Scientists reported that in the last eleven years, >there was a 273% increase in the diagnosis of Autism >and close to a 2000% increase in the diagnosis of >ADHD, Learning Disorders and Autism. >It is now becoming quite obvious even to medical >experts that the rate of Autism has dramatically >escalated in the 1990s. >It is my opinion that there are two subsets of Autism. >The first, which would not account for a dramatic >increase, is children who are destined to have Autism >at birth, a "metabolic/genetic problem." To account >for the dramatic increase in the diagnosis of Autism, >a significant number of children appear to have Autism >caused by an immune system stressor. Environmental >pollution, (especially pesticides), immunization >reactions, diet (especially starting cow's milk at >approximately one year of age), frequent use of >antibiotics to treat Otitis Media during the 1-1/2 >years of life appear to be significant risk factors. >In general, children with the "genetic/metabolic type" >who have delayed development before 12 months have a >more ominous prognosis. In contrast, children with the >later onset, who are noted to have normal development >followed by regression of speech, cognitive skills, >and social skills after one year of age often have a >much better prognosis. >In general, the earlier the diagnosis is made with >medical intervention, the better the prognosis. >A common medical history is a child with an increase >in ear infections requiring multiple courses of >antibiotics who has been started on cow's milk by one >year of age. There is often a positive allergy history >with multiple complaints--eye, ear, nose and >respiratory allergy, gastrointestinal complaints >(abdominal pain, limited appetite), increased food >cravings (especially milk, wheat, and sugar), urinary >symptoms (frequency), muscle and joint pain, and of >most significance the central nervous system. Often >there is a regression in speech, cognitive and social >skills. Children with this profile usually by 18-30 >months of age receive a diagnosis of Autism Spectrum >Disorder. >In recent years a growing number of parents point at >the MMR vaccine as the root cause of Autism. For at >least the past 10-15 years young children have been >receiving many combined vaccines before age two. This >includes 3 Hepatitis B, 4 DPT, 4 Polio, 3 HIB, >Chickenpox and the MMR vaccines by age two. By the >time the MMR is given at approximate 15 months, most >children have already received at least 10 >immunizations. Perhaps a child's immune system is not >ready at 15 months of age. >Most, if not all, autistic children have sensory >integration issues with hypersensitivity to sound, >touch, taste, pain and/or a vestibular proprioceptive >component. These children are also susceptible to >environmental chemical insult, especially pesticides >and food preservatives. I have yet to see a child with >Autism Spectrum Disorder who did not have sensory >modulation issues. The most prominent is sensitivity >to sound as many children with Autism hold their ears. >One should look for Auditory Processing Disorder as a >primary component in the diagnosis of Autism Spectrum >Disorder. >Dysbiosis/Leaky Gut Syndrome >A Leaky Gut manifests as an imbalance between bacteria >and yeast. Leaky gut is caused primarily by the >increased use of antibiotics leading to increased >intestinal permeability. With increased GI >permeability after antibiotics, good bacteria such as >Lactobacilli are destroyed whereas the Candida (yeast) >is not affected by antibiotics. Thus the integrity of >the gut wall membrane is adversely affected leading to >an imbalance of good and bad bacteria. This allows >nutrients and toxins to leak through the GI wall. The >consequence is a dysregulated immune system that often >results in behavior, development and learning >abnormalities. Antibiotics, casein/gluten products, >and sugar appear to be the leading causes of Leaky Gut >Syndrome. Patients having Leaky Gut and allergies >often have other hypersensitivities including dust, >pollen, additives and environmental chemicals. >Casein/Gluten-free diet >Children with Autism very often with ingestion of >casein/gluten related foods incompletely digest these >foods and develop gluten/casein peptides called >Gluteomorphine and Caseomorphine. These peptides are >partially digested and appear to react with opioid >receptors in the brain. This reaction mimics opiate >drugs such as heroin and morphine. The temporal lobe, >the center for language and social skills, is often >involved with developmental delay. Children with >Autism especially with a positive history of >antibiotic use should go on a casein and/or >gluten-free diet. This means the elimination of all >milk products, (cow's milk, cheese yogurt and ice >cream) as well as gluten products (wheat, oat, barley >and rye). >Other children respond to limiting sugar, milk >products, baked goods, junk food, craved food, >preservatives, and artificial flavorings. Supplements >to consider include B6, magnesium, calcium, DMG, Super >Nuthera, Amino Acids, Antioxidants (Beta Carotene, >Vitamins C and E, Selenium), Phosphatidyl Serine, >Piracetam, Digestive Enzymes, L-Glutathione, CoQ10, >Ginkgo, Essential Fatty Acids (especially Omega 3), >Folic acid, Biotin, Inositol, B Vitamins (B6 as well >as B1, 2, 3, 5, 12) and Vitamin D. >An anti-candida program should include probiotics to >control bacteria and yeast imbalance in the GI tract >by competing with candida for sugar. This includes FOS >(fructooligusaccharides) to promote the growth of good >bacteria. A probiotic should contain Lactobacillus, >Bifidus and FOS). Other supplements to control yeast >include garlic, grapeseed extract, caprylic acid, Pau >D'Arco tea, Olive Leaf Extract, Oil of Oregano, MCT >oil and Candicin. >Regarding antifungal medications to control yeast, >Nystatin should be considered first since this >medication is nontoxic, stays in the gut, is not >absorbed in the blood and does not adversely affect >the liver. Unfortunately, over the past ten years >there has been an increase in candida resistant >strains to Nystatin. >Of Diflucan, Nizoral, Sporanox and Lamisil, I >personally prefer Diflucan at a dosage of >approximately three milligrams per kilogram. If this >medication is used three months or longer, liver >function tests must be checked to be certain Diflucan >is not adversely affecting the liver. Nizoral, >Sporanox, Lamisil would also require liver function >tests every three months. >Therapies: Speech therapy, occupational therapy and >approximate school placement remain priorities. Other >medical approaches to consider include: >ABA program - (LoVaas) >Auditory Integration Training - Berrard, Tomatis, >Semores >Sensory Integration Program >Homeopathy >Herbal Therapy >Medications: >Some children with Autism Spectrum Disorder require >medication: Physicians should consider the following >meds: >Low dose Prozac starting with 1 milligram and >gradually increasing 1 milligram every two weeks to a >maximum of five milligrams. Prozac may help attention, >focus, as well as obsessive/compulsive behavior. >However, if the dosage of 5 milligrams is exceeded, >children are more likely to be hyperactive and have >insomnia. >The second medication I strongly consider is Tenex >which is primarily considered an antihypertensive or a >second line medication for ADHD. Tenex is an excellent >mood stabilizer and often has a calming effect for >autistic children. >Risperdal, which is considered to be an antipsychotic >is receiving more and more usage because of its >positive benefits for children with Autism. This >medication does have a number of side effects, but far >fewer than medications in the same family >classification--Haldol and Zyprexa. Currently, >double-blind control studies are being carried out in >several research centers around the country for the >use of Risperdal in Autism. >Antiviral medications such as Acyclovir (Zovirax) or >Amantadine have been advocated by several medical >experts. >Naltrexone is available from a compounding pharmacist >at a dose of three milligrams per day. Naltrexone has >an anti-opioid effect. >Intravenous Gamma Globulin based on the studies of Dr. >Gupta appears to be helping a number of children with >Autism. If interested in this treatment, I recommend >looking at the Good News Doctor website. Dr. Jeff >Bradstreet in Florida is providing IVIG and appears to >be having success. >Prednisone which has been studied at Jefferson Medical >School, is still favored by many pediatricians and >neurologists. >Lab Tests >Lab tests to consider include the following: >DAN Protocol to assess metabolic immune system >defects. >Organic acid testing by Dr. William Shaw. The urine >organic acid tests provides a metabolic marker for >increased fungal metabolites in the urine. Elevated >arabinose and tartaric acid can be helpful in >diagnosing a yeast problem. An increased DHPPA level >indicates anaerobic organisms and can be treated with >a medication such as Metronidazole (Flagyl) or a >supplement called Culturelle (Lactobacillus GG). >Comprehensive Digestive Stool Analysis (CDSA) from the >Great Smokies Lab. >Spect Scan can document decreased blood flow to the >temporal lobe. The temporal lobe is the center for >language and social skills. >Casein/gluten antibodies serum and urine. I prefer the >casein/gluten blood test to the urine IgA & IgG as I >am finding more positive results with the blood test. >With Autism, I would prefer to overdiagnose >casein/gluten than overlook this problem. >Personally I often order the CDSA, (comprehensive >digestive stool analysis) and casein/gluten >antibodies. For children receiving Secretin IV, I >order secretin antibody levels. >Books: >The books I recommend include the following: >Biologic Treatments for Autism PDD by William Shaw, >Ph.D. This in my opinion is the best single book on >Autism. >Special Kids, Special Diets by Lisa Lewis. This book >provides excellent information for the casein and/or >gluten-free diet. >Is This Your Child? by Doris Rapp, M.D. Although Dr. >Rapp's book focuses on the allergy/behavior/recurrent >infection connection, it can certainly help the child >with Autism as many as these children have significant >behavior issues. >Healing Childhood Ear Infections by Michael Schmidt, >Ph.D. Dr. Schmidt's book has a wealth of material on >herbal/homeopathic treatments. >The Out of Sync Child by Carol Kranowitz. This is an >excellent book on the sensory integration issue which >impacts most, if not all, children with autism. >To summarize, there certainly appears to be a >connection between the gastrointestinal tract immune >system and central nervous system. Leaky gut and food >allergies/hypersensitivities appear to have an adverse >impact on the temporal lobe--the speech and language >center for the brain.
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