Author:
Riley TR 3rd et al :Am J Gast 2001 Dec;96(12):3356-60
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Date Posted: Wed, January 16 2002, 12:21:37 PST
In reply to:
Anna Lok, MD Thomas Shehab MD Mauricio Orrego, M.D. UMich
's message, "Doctors/Patients Not Following Through on Hepatitis C Screening" on Mon, July 30 2001, 8:16:52 PDT
Am J Gastroenterol 2001 Dec;96(12):3356-60
Riley TR 3rd, Chinchilli VM, Shoemaker M, Koch K.
Department of Medicine and Health Evaluation Sciences, The Pennsylvania
State University-The Hershey Medical Center, 17033, USA.
OBJECTIVES: Hepatitis C virus is a common chronic infection that is widely
associated with symptoms of fatigue and pain in the right upper quadrant.
Nausea may be an underrecognized symptom. This study was designed to study
the frequency of nausea in patients with hepatitis C virus infection
compared to controls.
METHODS: A cross-sectional study design with
consecutive outpatients was used. Three groups were administered a
dyspepsia and a previously validated Nausea Profile questionnaire.
Univariate and multivariate analysis was performed.
RESULTS: A total of 64
hepatitis C virus (HCV) patients, 53 liver disease controls (LC), and 64
normal controls (NC) were studied. An increased period prevalence of nausea
was found in HCV patients 43% versus 29.7% in NC and 18.9% in LC (p =
0.009). There was an increased frequency of fatigue and abdominal pain in
HCV patients over 1 month compared to LC and NC combined (p = 0.0001 and
0.0065 respectively). The Nausea Profile score revealed statistically
higher total scores and higher subscale scores in the HCV group compared to
controls. The total NP score expressed as a percentage of the maximum was
27% in HCV versus 12.7% for LC and 9.2% for NC (p = 0.0005). The odds of
nausea using logistic regression were 2.1 CI (1.0-4.5) in HCV patients
compared to controls (p = 0.05). Using linear regression, higher Nausea
Profile scores were found to be independently associated with the diagnosis
of HCV (.0005), fatigue (p = 0.0003), and abdominal pain (p = 0.0001).
CONCLUSIONS: HCV infection is associated with an increased risk for nausea.
The strong association between abdominal pain and nausea may be a clue to
the etiology of nausea in these patients. Further etiological studies are
needed.
PMID: 11774949 [PubMed - in process]
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