Author:
Morin T, Pariente A; Gastroenterol Clin Biol 2002 Nov;26(11):994-1000
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Date Posted: Wed, January 08 2003, 6:33:51 PST
In reply to:
Teresa Hanbey
's message, "Treatment of acute cases of hepatitis C: Marketing or science?" on Tue, October 02 2001, 8:13:25 PDT
Gastroenterol Clin Biol 2002 Nov;26(11):994-1000
[Acute Hepatitis C: a retrospective study of 62 cases]
[Article in French]
Morin T, Pariente A.
Association Nationale des Gastroenterologues des Hopitaux generaux (ANGH).
OBJECTIVES: Retrospective study of acute hepatitis C cases observed in general hospitals.
METHODS: Questionnaire sent by mail to members of the Association Nationale des Gastroenterologues des Hopitaux Generaux (ANGH) in December, 1997. Data were updated in September, 2001.
RESULTS: Sixty-two cases were reported in 40 centers. Patients were predominantly female (58%), the median age was 33 years-old. Symptoms revealed the disease in 65% of cases (jaundice in 53%) and screening in 30%. The main suspected routes of infection were intravenous drug use (32%), nosocomial exposure (29%) and professional accidents (11%). Sustained viral clearance occurred in 12 out of the 28 patients who were followed without treatment for 6 months, in 14 of 30 treated early, and 4 out of 7 treated secondarily with interferon alpha alone. No prognostic factor was identified, except for a low total dose of interferon in treated patients.
CONCLUSIONS: Acute hepatitis C is a rare disease, occuring in younger and more often in female patients than chronic hepatitis C. Spontaneous cure is not infrequent, and could justify a period of simple follow-up before starting treatment. A national observatory would help for epidemiologic surveillance and therapeutic studies.
PMID: 12483131 [PubMed - in process]
Hepatitis C Outreach Project
www.hcop.org
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