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Date Posted: 08:49:13 07/27/06 Thu
Author: sundaymorning
Subject: does it give a time frame?
In reply to: Steve in ATL 's message, "Interesting..." on 08:44:56 07/27/06 Thu

>The Effect of Alcohol Consumption on the Urinary
>Testosterone / Epitestosterone Ratio
>
>
>By Dr Simon Davis B.Sc., Ph.D.
>
>
>Summary
>
>
>Intoxicating beverages contain a number of different
>forms of alcohol, the major constituent of which is
>ethanol. When a beverage is consumed the ethanol
>content passes through the stomach wall and digestive
>tract into the blood stream. Once the ethanol enters
>circulation it begins to alter the bodies'
>biochemistry. One such reaction is to differentially
>increase the rates of testosterone (T) and
>epitestosterone (E) metabolism. The overall effect of
>this reaction is to increase the ratio of T to E
>excreted in the urine.
>
>
>It has been reported that ethanol consumption can
>increase urinary T/E ratios by 30% - 277% in healthy
>individuals. Observed changes in plasma T/E ratios
>can occur with the consumption of less than 2 pints of
>lager. The ingestion of ethanol by an individual will
>increase the T/E ratio observed in a urine sample.
>
>
>It follows that if the effect of ethanol on T/E ratios
>is calculated relative to urinary E concentrations, it
>can be seen that increases in the ratio are
>exponential as E concentrations decrease. Individuals
>with naturally low E concentrations could, therefore,
>experience increases in T/E ratios of ? 940% greater
>than increases experienced in an individual with
>normal E concentrations. Calculations estimate that
>in individuals with low urinary E concentration,
>ratios of 17 to 1 or higher could have resulted from
>ethanol consumption without any administration of
>exogenous T.
>
>
>The current T/E ratio test as performed by Kings
>College Laboratory and approved by the UK Sports, the
>IWF and IOC cannot discriminate between a 13 to 1 T/E
>ratio resulting from ethanol ingestion or a 13 to 1
>ratio resulting from endogenous T administration.

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