VoyForums
[ Show ]
Support VoyForums
[ Shrink ]
VoyForums Announcement: Programming and providing support for this service has been a labor of love since 1997. We are one of the few services online who values our users' privacy, and have never sold your information. We have even fought hard to defend your privacy in legal cases; however, we've done it with almost no financial support -- paying out of pocket to continue providing the service. Due to the issues imposed on us by advertisers, we also stopped hosting most ads on the forums many years ago. We hope you appreciate our efforts.

Show your support by donating any amount. (Note: We are still technically a for-profit company, so your contribution is not tax-deductible.) PayPal Acct: Feedback:

Donate to VoyForums (PayPal):

[ Login ] [ Contact Forum Admin ] [ Main index ] [ Post a new message ] [ Search | Check update time | Archives: [1] ]

[ Next Thread | Previous Thread | Next Message | Previous Message ]

Date Posted: 14:01:44 03/13/03 Thu
Author: Alexandre
Subject: Artificial human liver created (bbcnews.com)

Patients with liver failure could be helped by an machine that uses human liver cells to remove poisons from the blood.
Approximately 5,000 people die from liver failure each year in England and Wales.

Only just over 500 liver transplants are carried out.

However, while kidney failure patients can go on dialysis while they wait for a transplant, options for liver patients are more limited.

Mechanical filters exist which can remove some of the toxins from the blood, but scientists are looking for more effective methods.

Pig viruses

Other "liver assist systems" have been developed which involve filtering the blood plasma through pig liver cells.

However, this raises fears about unknown diseases from pigs finding their way back into humans.

This device could serve as a bridge to successful transplantation, helping to sustain patients awaiting a donor organ

Dr Roshan Shresta, University of North Carolina
The ELAD system developed in the US is the first to use liver cells from humans to perform the same task.

Patients are attached to the machine by a catheter into a neck vein, and the blood is initially put through a mechanical filtration process to remove some waste products.

Then the blood plasma is passed through cartridges containing the hepatic cells before being returned to the body.

Dr Roshan Shresta, who is organising a trial of the system at the University of North Caroline at Chapel Hill, said: "Currently, we don't have very good therapies for patients with acute liver failure.

"That's why we're hoping that the new technology will make a big difference.

"This device could serve as a bridge to successful transplantation, helping to sustain patients awaiting a donor organ."

Full recovery

He added: "A remarkable feature of the liver is its capacity to regenerate.

"If we can sustain acute liver failure patients early on, right from the beginning, they may not need transplantation and may recover."

A small-scale study of just 16 patients given the treatment found that the condition of 13 of them improved.

Nigel Hughes, the chief executive of the British Liver Trust, said that the arrival of a device using human cells would be a "major step forward".

He said: "Obviously such treatment would be very expensive, but it could be extremely beneficial."

He said that he would have concerns if the human liver cells had been treated to make them "immortal".

"Cells like these would share many qualities with cancer cells, and it would be important to make sure none of them got into the patient."

[ Next Thread | Previous Thread | Next Message | Previous Message ]
[ Contact Forum Admin ]

Forum timezone: GMT-5
VF Version: 3.00b, ConfDB:
Before posting please read our privacy policy.
VoyForums(tm) is a Free Service from Voyager Info-Systems.
Copyright © 1998-2019 Voyager Info-Systems. All Rights Reserved.