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Date Posted: 15:35:18 06/29/04 Tue
Author: J.R.Smith,c.f.t.,s.p.n.,s.s.c.
Subject: Liposuction doesn't address metabolic problems

Liposuction Doesn't Change Metabolic Problems


Liposuction doesn't address metabolic problems
By Anthony J. Brown, MD

Wednesday, June 16, 2004



NEW YORK (Reuters Health) - Obesity is associated with various metabolic problems that raise the risk of heart disease. Now, new research indicates that although liposuction can produce dramatic weight loss, the operation does nothing to address the metabolic issues.

"From previous studies there was a suggestion that liposuction might improve some of the metabolic abnormalities associated with obesity--mainly the risk factors for heart disease," lead author Dr. Samuel Klein, from Washington University in St. Louis, told Reuters Health. "But there were some flaws and limitations with those studies."

With the newer liposuction techniques developed in the last decade, "you can now remove much larger volumes of fat than previously," Klein explained. "So, we thought it would it would be worthwhile to reevaluate liposuction as a potential treatment for obesity-related metabolic abnormalities."

Even with a relatively large amount of fat removal, there was no evidence that liposuction altered the patients' metabolic abnormalities, Klein said.

The study, which is reported in The New England Journal of Medicine, involved 15 obese women who were assessed before and 12 weeks after undergoing liposuction. Seven of the women had type 2 diabetes.

As expected, liposuction was associated with substantial reductions in body fat and body weight. Despite these effects, there was no change in the patients' metabolic abnormalities, such as poor sensitivity to insulin and elevated blood levels of certain inflammation proteins. In addition, the operation did not reduce high cholesterol levels or high blood pressure.

"This study does help us reevaluate the whole paradigm of what weight loss does for obese people," Klein said. "With liposuction, you're removing whole fat cells -- you're not changing the remaining fat cells and you're not removing fat that is present in (other) tissues, like liver and muscle. In contrast, with dieting, there is a general shrinking of all fat cells that seems to have beneficial metabolic effects."

Klein noted that because it is a forced type of dieting, stomach-stapling surgery, unlike liposuction, does have a beneficial effect on metabolic parameters.

SOURCE: The New England Journal of Medicine, June 17, 2004.

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