| Subject: Viagra - Buy Viagra Online |
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Date Posted: 00:53:37 05/12/06 Fri
In reply to:
phentermine
's message, "phentermine" on 21:28:48 10/27/05 Thu
Viagra
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Viagra
Name: Sildenafil citrate
Product name: Viagra
Appearance: blue pill, Label "Pfizer" on one side, "VGR xx" on the other. XX represents dose of active substance in one pill. For example, VGR 50 means that it is Viagra 50 mg, one tablet contains 50mg of Sildenafil citrate.
Manufacturer: Pfizer - pharmaceutical company
Chemical name: 1-[4-ethoxy- 3-(6,7-dihydro- 1-methyl- 7-oxo- 3-propyl- 1 H -pyrazolo [4,3- d ]pyrimidin-5-yl) phenylsulfonyl]- 4-methylpiperazine citrate
Molecular weight: 666.7 g/mol
Picture of molecular structure:
How it works:
One part of of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum . This activates the enzyme guanylate cyclase and result is increased levels of cyclic guanosine monophosphate (cGMP) which leads to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection.
Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 ( PDE5 ) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with Viagra on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, Viagra should not cause an erection
In common words:
Drug works by increasing blood flow to the penis. It is not a hormone or an aphrodisiac. Once you take it, Viagra can work in as quickly as 30 minutes. VIAGRA works for 4 hours so you can set your own pace. If taken with a high fat meal, there may be a delay in absorption of Viagra and the net effect might be muted slightly as the plasma concentration will be lowered. Some reports say that Viagra can causeenhanced sexual pleasure for women! It is by increasing blood flow to their sexual organs.
Dosage: The dose of Viagra is 25mg to 100mg taken once per day between 0.5 to 4 hours before sexual activity, but as all prescription drugs, proper dosage is at the discretion of a licensed doctor. It is recommended to start with a dosage of 50 mg and then lower or raise the dosage as appropriate.
Attention!:
Viagra as a pill isn't scored, meaning there is no guarantee that the drug is evenly distributed throughout the tablet. It is not advisable to split it in pill-splitters to change a dose to half.
Official contraindications include:
When taking other nitric oxide donors, organic nitrites and nitrates (which includes glyceryl trinitrate , sodium nitroprusside , amyl nitrite )
In men for whom sexual intercourse is inadvisable due to cardiovascular risk factors
Severe hepatic impairment
Severe impairment in renal function
Hypotension
Recent stroke or heart attack ( myocardial infarct )
Hereditary degenerative retinal disorders (including genetic disorders of retinal phosphodiesterases )
Amongst Viagra's serious adverse effects are: priapism , severe hypotension , myocardial infarction , ventricular arrhythmias , sudden death, stroke and increased intraocular pressure.
Common side efects: sneezing, headache, flushing, dyspepsia, prolonged erections, palpitations and photophobia. Visual changes including blurring of vision and a curious bluish tinge
What is an Erectile Dysfunction:
ED can be a physical problem. Normally, when a man is sexually excited, his penis fills with more blood than usual and it becomes erect or hard. When a man has ED, his penis does not fill with enough blood to get erect or hard. Or it may not stay erect long enough to complete sex.
Many men have this health problem. In fact, about 30 million men in the United States have ED to some degree. And studies show that about half of the men between the ages of 40 and 70 have ED to some degree.
Viagra history:
Our blue pill was initially developed to treat heart disease ( angina ). During trial studies, the penile erection enhancing effects were noticed.
The drug was patented in 1996 , approved by the FDA on March 27 , 1998 (becoming the first pill approved to treat erectile dysfunction in the United States) and offered for sale in the United States later that year. It soon became a smashing success.
Even though Viagra is only available by prescription from a doctor, it was advertised directly to consumers on TV (famously being endorsed by Bob Dole ). It is likely that many men (and some women) experiment with the drug to increase sexual prowess or pleasure.
Competitors:
There are other drugs that work on same mechanism. The most famous are Cialis and Levitra.
Other important Viagra sites:
Viagra home page
Pfizer home page
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