| Subject: Re: HPV and Oral Cancer and vaccine: |
Author:
Myra
| [ Next Thread |
Previous Thread |
Next Message |
Previous Message
]
Date Posted: Tuesday, November 28, 06:12:39pm
Author Host/IP: 208.54.94.26
In reply to:
Lauren
's message, "HPV and Oral Cancer and vaccine:" on Monday, November 27, 07:45:44am
The HPV vaccine Gardasil by Merck has been approved for women between the ages of 9 and 26. The vaccine can be given to women if they have had warts or have had cervical lesions. The vaccine is not a treatment and does not replace the yearly Pap/pelvic exam. The vaccine is said to be more effective if give before sex but getting the vaccine at a later time may provide protection from other HPV types that you have not acquired.
The vaccine is said to be a preventative for two low risk HPV types 6 and 11 and two high risk HPV types 16 and 18. These are the most common HPV types but they are over 30 HPV low and high risk HPV types.
Oral cancer has its link with HPV but smoking is still the biggest risk factor. Your best place for information on oral cancers is the oral cancer foundation.
http://www.oralcancerfoundation.org/facts/hpv_reports.htm
http://www.hivdent.org/slides/human_papilloma_virus.htm
http://www.hivdent.org/slides/hpv_ie1.htm
http://www.hivdent.org/slides/hpv_ie2.htm
http://www.hivdent.org/slides/hpv_ie3.htm
There is also a test for precancer of the oral area. Ask your dentist about doing the Vizilite screening.
Women face a high risk factor for developing anal problems then men that have had sex with men. A great slide show from Dr. Palefsky can be found on Medscape.
Engaging in anal sex is a risk factor but women who have never participated in anal sex had developed anal cancer. About 90% of all anal cancer is linked to HPV.
I am enclosing a couple of article on anal cancer and on oral cancer. You may also want to join our HPV info group. We keep current medial and media information here. You can find lots of information on the vaccine cervical dysplasia, VIN, and anal cancer.
http://health.groups.yahoo.com/group/hpvgyngalinfo/
Anal HPV more prevalent than cervical HPV in HIV-positive women
Derek Thaczuk, Thursday, October 19, 2006
Research in human papilloma virus (HPV) in women has mostly focused
on cervical HPV; not much is known about anal HPV infection in women.
A team of American researchers therefore investigated the prevalence
(frequency of occurrence) and diversity (number of different viral
strains) of HPV in HIV-positive women, finding that the virus is
actually more prevalent and more diverse anally than cervically. The
research was presented to the recent meeting of the Infectious
Diseases Society of America in Toronto.
HPV is the name for a family of sexually transmitted viruses which
includes dozens of different subtypes. Some of these subtypes cause
genital and anal warts; others can lead to cervical cancer in women,
or anal cancer in people of either sex. People with damaged immune
systems are at increased risk of HPV-related cancers.
The SUN Study (Study to Understand the Natural History of HIV/AIDS in
the Era of Effective Therapy) is a five-year, prospective
observational study that aims to enroll 1000 HIV-positive
participants through seven U.S. centres. As part of the SUN study,
122 women provided information about sexual risk factors, and had
cervical and anal swabs analysed for human papilloma virus. The women
ranged between 21 and 64 years of age (average 40), were racially
diverse, and had median CD4 cell counts of 419 cells/mm3 and viral
load of 1.7 log10.
In all, 112 (92%) of the women were found to have HPV. All strains of
HPV were more commonly found by anal than by cervical swab (92% vs.
86%; high-risk types for cancer 84% vs. 64%; low-risk types 74% vs.
59%). A larger number of different HPV subtypes were also found in
the anus, as compared to the cervix: this was true at all CD4 count
levels, and for high-risk and low-risk subtypes for cancer. The
actual subtypes themselves varied: of the types considered high-risk
for cancer, types 16, 35, 53, 58 and 59 were most prevalent in the
cervix; types 16, 18, 31, 45, 53 and 58 were most prevalent in the
anus. (Viral subtypes 16 and 18 are considered the most `oncogenic',
or likely to cause cancer: currently available `quadrivalent' HPV
vaccines are active against viral subtypes 6, 11, 16 and 18.)
Since the group did not include many women with very low CD4 cell
counts, the researchers could not really gauge CD4 count as a risk
factor. They did, however, find that having had anal sex did not
appear to be a risk factor for anal HPV. They concluded that "there
is a need to further investigate the clinical significance of anal
HPV infection in women." Also, since currently available HPV vaccines
are based on a few specific high-risk subtypes, they state that "HPV
vaccine efficacy needs to be evaluated in HIV-positive women."
• 10/5/2006
• Washingoton, D.C.
• Carole Fakhry et al.
• J. Clin. Microbiol. doi:10.1128/JCM.01321-06
Human Papillomavirus (HPV) is an etiologic agent for both oropharyngeal and cervical cancers, and yet, little is known about the interrelationship between oral and cervical HPV infection. Therefore, we compared the prevalence and type distribution of oral and cervical HPV infection and evaluated infection concordance in a cross-sectional study within the Womens' Interagency HIV Study (WIHS) cohort.
Oral rinse and cervical vaginal lavage samples were concurrently collected from a convenience sample of 172 HIV-positive and 86 HIV-negative women. HPV genomic DNA was detected by PGMY09/11 L1 consensus primer PCR and type specified by reverse line blot hybridization for 37 HPV types and B-globin. Only 26 of the 35 HPV types found to infect the cervix were also found within the oral cavity, and the type distribution for oral HPV infections appeared distinct from that for cervical infections ( p<0.001). Oral HPV infections were less common than cervical infections for both HIV-positive (25.2% vs. 76.9%, p<0.001) and HIV-negative (9.0% vs. 44.9%, p<0.001) women. Oral HPV infections were more common among women with a cervical HPV infection (25.5% vs. 7.9%, p=0.002).
The majority of women (207, 93.7%) did not have a simultaneous oral and cervical infection by the same HPV type, however, the number of women who did (14, 6.3%) was significantly greater than would be expected by chance (p=0.0002). Therefore, the oral and cervical reservoirs for HPV infection are likely not entirely independent of one another.
Authors:
Carole Fakhry, Gypsyamber D'souza, Elizabeth Sugar, Kathleen Weber, Eleni Goshu, Howard Minkoff, Rodney Wright, Eric Seaberg, and Maura Gillison
Authors' affiliation:
Johns Hopkins Medicine; Johns Hopkins Bloomberg School of Public Health; The CORE Center at John H. Stroger Jr Hospital of Cook County; Maimonides Medical Center; Albert Einstein College of Medicine
[
Next Thread |
Previous Thread |
Next Message |
Previous Message
] |
|
Feedback: 