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Subject: SUSTANON '250'ampoules


Author:
sustanon 250
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Date Posted: 08:57:18 11/10/04 Wed

SUSTANON '250'ampoules
SCHEDULING STATUS: S5
PROPRIETARY NAME (and dosage form) SUSTANON '250'ampoules


COMPOSITION: Each mL of the oily solution contains:

testosterone propionate 30 mg
testosterone phenylpropionate 60 mg
testosterone isocaproate 60 mg
testosterone decanoate 100 mg
benzyl alcohol 10% v/v
PHARMACOLOGICAL CLASSIFICATION: A/21.7/Male sex hormones.
PHARMACOLOGICAL ACTION: Sustanon '250'is an androgenic preparation for intramuscular administration containing four different ester of the natural hormone testosterone.

INDICATIONS: Testosterone replacement therapy in male hypogonadal disorders, for example:

after castration
eunuchoidism
hypopituitarism
Moreover, testosterone therapy may be indicated in osteoporosis due to
hypogonadal male androgen deficiency.

CONTRA-INDICATIONS: Known or suspected mammary or prostatic carcinoma in the male. This medicine is not intended for use in female patients.


WARNINGS: Middle-aged and elderly males with angina pectoris or other severe circulatory disease should receive androgen treatment only under very careful supervision.

DOSAGE AND DIRECTIONS FOR USE: In general, dosage should be adjusted according to the response of the individual patient. Usually, one injection of 1 mL per four weeks is adequate. SUSTANON '250'should be administered by deep intramuscular injection.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS: The following adverse reactions have been associated with androgen therapy:

Priapism and other signs of excessive sexual stimulation.
In prepubertal boys: precocious sexual development, an increased frequency of erections, phallic enlargement and premature epiphyseal closure.
Oligospermia and decreased ejaculatory volume.
Water and salt retention.
Precautions: If androgen-associated adverse reactions occur, treatment should be interrupted and, after disappearance of the symptoms, be resumed at a lower dosage. Patients with latent or overt cardiac failure, renal dysfunction, hypertension, epilepsy or migraine (or a history of these conditions) should be monitored, since androgens may occasionally induce salt and fluid retention.

Androgens should be used cautiously in prepubertal boys to avoid premature epiphyseal closure or precocious sexual development. A decrease in protein bound iodine (PBI) may occur, but this has no clinical significance.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT

See "Side-effects and Special Precautions". Treat symptomatically.

CONDITIONS OF REGISTRATION: Advertising to the professions only.

IDENTIFICATION: An ampoule marked with a red and yellow stripe on the neck, containing a clear oily solution.

PRESENTATION: SUSTANON '250'1 mL ampoules -boxes of 3

STORAGE DIRECTIONS: The ampoules andS syringes should be kept at room temperature and protected from light.

Keep out of reach of children.

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