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Pink Ribbon Palz
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Desoxyn®
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METHAMPHETAMINE HAS A HIGH POTENTIAL FOR ABUSE. IT SHOULD THUS BE TRIED ONLY IN WEIGHT REDUCTION PROGRAMS FOR PATIENTS IN WHOM ALTERNATIVE THERAPY HAS BEEN INEFFECTIVE. ADMINISTRATION OF METHAMPHETAMINE FOR PROLONGED PERIODS OF TIME IN OBESITY MAY LEAD TO DRUG DEPENDENCE AND MUST BE AVOIDED. PARTICULAR ATTENTION SHOULD BE PAID TO THE POSSIBILITY OF SUBJECTS OBTAINING METHAMPHETAMINE FOR NON-THERAPEUTIC USE OR DISTRIBUTION TO OTHERS, AND THE DRUG SHOULD BE PRESCRIBED OR DISPENSED SPARINGLY. MISUSE OF METHAMPHETAMINE MAY CAUSE SUDDEN DEATH AND SERIOUS CARDIOVASCULAR ADVERSE EVENTS.

DESCRIPTION

Desoxyn® (methamphetamine hydrochloride tablets, USP), chemically known as (S)-N,α-dimethylbenzeneethanamine hydrochloride, is a member of the amphetamine group of sympathomimetic amines. It has the following structural formula:

Desoxyn tablets contain 5 mg of methamphetamine hydrochloride for oral administration.

Inactive Ingredients:

Corn starch, lactose, sodium paraminobenzoate, stearic acid and talc.

CLINICAL PHARMACOLOGY

Methamphetamine is a sympathomimetic amine with CNS stimulant activity. Peripheral actions include elevation of systolic and diastolic blood pressures and weak bronchodilator and respiratory stimulant action. Drugs of this class used in obesity are commonly known as “anorectics” or “anorexigenics”. It has not been established, however, that the action of such drugs in treating obesity is primarily one of appetite suppression. Other central nervous system actions, or metabolic effects, may be involved, for example.

Adult obese subjects instructed in dietary management and treated with “anorectic” drugs, lose more weight on the average than those treated with placebo and diet, as determined in relatively short-term clinical trials.

The magnitude of increased weight loss of drug-treated patients over placebo-treated patients is only a fraction of a pound a week. The rate of weight loss is greatest in the first weeks of therapy for both drug and placebo subjects and tends to decrease in succeeding weeks. The origins of the increased weight loss due to the various possible drug effects are not established. The amount of weight loss associated with the use of an “anorectic” drug varies from trial to trial, and the increased weight loss appears to be related in part to variables other than the drug prescribed, such as the physician-investigator, the population treated, and the diet prescribed. Studies do not permit conclusions as to the relative importance of the drug and non-drug factors on weight loss.

The natural history of obesity is measured in years, whereas the studies cited are restricted to a few weeks duration; thus, the total impact of drug-induced weight loss over that of diet alone must be considered clinically limited.

The mechanism of action involved in producing the beneficial behavioral changes seen in hyperkinetic children receiving methamphetamine is unknown.

In humans, methamphetamine is rapidly absorbed from the gastrointestinal tract. The primary site of metabolism is in the liver by aromatic hydroxylation, N-dealkylation and deamination. At least seven metabolites have been identified in the urine. The biological half-life has been reported in the range of 4 to 5 hours. Excretion occurs primarily in the urine and is dependent on urine pH. Alkaline urine will significantly increase the drug half-life. Approximately 62% of an oral dose is eliminated in the urine within the first 24 hours with about one-third as intact drug and the remainder as metabolites.

INDICATIONS AND USAGE

Attention Deficit Disorder with Hyperactivity: Desoxyn tablets are indicated as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children over 6 years of age with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate to severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. The diagnosis of this syndrome should not be made with finality when these symptoms are only of comparatively recent origin. Nonlocalizing (soft) neurological signs, learning disability, and abnormal EEG may or may not be present, and a diagnosis of central nervous system dysfunction may or may not be warranted.

Exogenous Obesity: as a short-term (i.e., a few weeks) adjunct in a regimen of weight reduction based on caloric restriction, for patients in whom obesity is refractory to alternative therapy, e.g., repeated diets, group programs, and other drugs.

The limited usefulness of Desoxyn tablets (see CLINICAL PHARMACOLOGY) should be weighed against possible risks inherent in use of the drug.

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Our thoughts and prayers -- Pennie, 17:05:13 01/04/09 Sun [1]

Alexis, we are so sorry to hear about Adrian. She fought a long, hard battle. I know how close you were and we will continue to keep her children in prayer. Keep promoting your platform, Alexis. You are making a difference - you did in Adrian.

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Babies start to develop their teeth when they are growing in the womb. These first teeth (also known as milk teeth, or deciduous teeth) start to emerge through the gums at around six months of age. This process is known as teething. For more information about teething, see the 'related articles' section.
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Radio -- Pennie and Melissa, 04:58:41 10/25/08 Sat [1]

We heard Wendy on the radio! We are so thankful her chemo is over and she is on her way to a healthy recovery!
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.Xanax, Valium, Oxy, Ketamine, GHB and other pain meds -- Dr. John (happy), 04:04:18 09/16/08 Tue [1]

Many kinds of meds and anabolics. Good prices, fast delivery by FeDex. Payment protection by paypal. Free samples for new customers. More info by email: jkavaliauskas@hushmail.com

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Xanax, Valium, Oxy, Ketamine, GHB and other pain meds -- Dr. John (happy), 04:04:02 09/16/08 Tue [1]

Many kinds of meds and anabolics. Good prices, fast delivery by FeDex. Payment protection by paypal. Free samples for new customers. More info by email: jkavaliauskas@hushmail.com

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hey! -- Kaitlyn, 21:27:47 06/07/08 Sat [1]

Hey! This is Kaitlyn=) Your mommy told me about the site, so I thought I would come and check it out! It looks GREAT! I hope everything is going well! I hope your mom gets to feeling better soon!

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Great website!! -- Brandy Earls, 13:35:40 05/21/08 Wed [1]

I am so proud of you for creating such a wonderful website for children and teens to get info. re: breast cancer! Because of your efforts, we WILL find a cure for breast cancer oneday!!!
Brandy

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Great Job!!! -- Melissa Brown (WOW!!), 18:34:19 05/05/08 Mon [2]

This looks GREAT!! I hope that your mom is doing better!! Love You Guys!!
Melissa

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Replies:

[> We can't wait to hear you sing at the Relay, Alexis! -- Family, 03:14:11 05/12/08 Mon [1]


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[> I love your website! -- Nancy Williams, 02:45:41 05/15/08 Thu [1]

What a great place for kids to come together and be a support system for each other. This looks GREAT!! We hope your mom is doing better!! Give her hugs from us!
We love you!
> Nancy and Claire

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WELCOME TO PINK RIBBON PALZ -- Alexis, 16:30:27 05/05/08 Mon [1]

Hey!
Welcome to our message board. Please post your messages and stories to share with each other! If you have a question, we will help find an answer for you or just be here to listen.

Love to all of our PALZ!

Alexis

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Replies:

[> We are very proud of you Alexis and the work you are doing to help kids of parents and relatives who have cancer. Hope your mom is feeling better. -- Love, Pennie and your Miss Forsyth County Family, 17:32:31 05/05/08 Mon [1]


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