OXYCODONE DOSAGE -- oxycodone online

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Subject: OXYCODONE DOSAGE

Author:
percocet kingpin

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Date Posted: 07:07:23 08/11/11 Thu

Usual Adult Dose for:

Pain

Usual Geriatric Dose for:

Pain

Usual Pediatric Dose for:

Pain

Additional dosage information:

Renal Dose Adjustments
Liver Dose Adjustments
Dose Adjustments
Precautions
Other Comments

Usual Adult Dose for Pain

Initial:
Immediate Release (IR): 5 mg to 15 mg orally every 4 to 6 hours
Controlled Release (CR): 10 mg orally every 12 hours.

Maintenance:
IR: 10 mg to 30 mg orally every 4 hours. Doses greater than 30 mg are rarely needed and should be used with great caution.
CR: 20 mg to 640 mg per day in patients with cancer pain. The average total daily dose is approximately 105 mg per day. Cancer patients with severe pain may require "as needed" rescue doses of the immediate-release form of oxycodone to supplement the controlled-release form.
Usual Geriatric Dose for Pain

Initial:
Immediate Release (IR): 2.5 mg orally every 6 hours

Maintenance:
IR: Increase dose slowly as needed. Doses greater than 30 mg are rarely needed and should be used with great caution.
CR: 20 mg to 640 mg per day in patients with cancer pain. The average total daily dose is approximately 105 mg per day. Cancer patients with severe pain may require "as needed" rescue doses of the immediate-release form of oxycodone to supplement the controlled-release form.
Usual Pediatric Dose for Pain

> 1 year <50 kg: 0.05 mg to 0.15 mg/kg/dose every 4 to 6 hours as needed.
> 1 year >=50 kg: Start at 5 mg orally every 6 hours as needed, then dose may be titrated up to 10 mg orally every 3 to 4 hours.
Renal Dose Adjustments

Creatinine Clearance less than 60 mL/minute: Start conservatively and titrate dosage carefully to desired effect.
Liver Dose Adjustments

Initial: Give one-third to one-half of the usual dose; titrate dosage carefully to desired effect.
Dose Adjustments

The dose should be adjusted according to severity of pain, patient response and patient size.

As needed "rescue doses" of immediate release oxycodone may be needed for patients with cancer pain. Rescue doses should be one-fourth to one-third of the 12-hour controlled release oxycodone dose.

Patients with doses > 60 mg/day should be tapered off the medication over several days.
Precautions

Oxycodone, particularly in large doses, may cause life-threatening respiratory depression. Treatment includes maintenance of the airway, artificial ventilation if necessary, and use of the opiate antagonist naloxone. (The usual adult dose of naloxone is 1 to 2 mg every 5 minutes as necessary. The dose can be administered intravenously, intramuscularly, subcutaneously, and sublingually.)

The drug has an abuse liability similar to morphine. This should be considered when prescribing or dispensing oxycodone in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion.

Oxycodone, like other narcotic analgesics, should be administered with caution to patients with head injuries, increased intracranial pressure, acute undiagnosed abdominal pain, circulatory shock, respiratory depression, hypothyroidism, severe renal and/or liver disease, Addison's disease, prostatic hypertrophy, urethral stricture, acute alcoholism, delirium tremens, seizure risk, biliary tract disease, and general debilitation.

The controlled-release form of oxycodone should not be broken, chewed, or crushed as this could lead to a faster release and absorption of oxycodone, potentiating toxicity

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