Phage Lamda -- Molecular Biology

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Date Posted: 11:32:43 05/28/99 Fri
Author: Sumit Dua
Subject: Phage Lamda

I got a question on phage lamda. I went over this in detail in class, but I wrote a quick response from memory real fast. I am posting here, so you can look at it. If there are any mistakes in it please let me know. Also, look this info up in your book, this is a real quick guide, and not to be taken as the sole information because, like I said, it might have a mistake or so.

When the whole thing starts transcription is going from P(l) to t(l) and from P(r) to t(r). The l and r are left and right. The cro and the n are being manufactured in small quantities. cI is mainly present, and binds
to or1 and or2. This increases its own production. cI represses lytic phase. On the outside of chromosome are the lytic genes, such as Q and S and these have to be manufactured and only way is if transcrip goes
further than t(l) and t(r). I can't draw a pic of the chromosome here. So cI, when it gets too high binds to or3 and represses itself. This is called AUTOREGULATION. Now the cro that was being made a little before,
likes to bind mainly to or3 and now when cI is repressed it does. This causes transcription to go past t, left and right. Thus cro represses lysogenic phase. cII makes synthesis of cI go up, and is after t l and r.
So this is made after cro comes in. cIII just saves cII from being degraded by Hf1 protease.

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Replies:

Re: Phage Lamda -- Mike Ozawa, 16:53:18 12/06/99 Mon