VoyForums
[ Show ]
Support VoyForums
[ Shrink ]
VoyForums Announcement: Programming and providing support for this service has been a labor of love since 1997. We are one of the few services online who values our users' privacy, and have never sold your information. We have even fought hard to defend your privacy in legal cases; however, we've done it with almost no financial support -- paying out of pocket to continue providing the service. Due to the issues imposed on us by advertisers, we also stopped hosting most ads on the forums many years ago. We hope you appreciate our efforts.

Show your support by donating any amount. (Note: We are still technically a for-profit company, so your contribution is not tax-deductible.) PayPal Acct: Feedback:

Donate to VoyForums (PayPal):

[ Login ] [ Contact Forum Admin ] [ Main index ] [ Post a new message ] [ Search | Check update time | Archives: 1, [2], 3, 4 ]

[ Next Thread | Previous Thread | Next Message | Previous Message ]

Date Posted: 20:14:17 07/24/02 Wed
Author: moonotter
Subject: Nevirapine May Protect Against HIV Transmission From Sexual Or Blood Exposure

Nevirapine May Protect Against HIV Transmission From Sexual Or Blood Exposure


Reuters Health Information 2002. © 2002 Reuters Ltd.
Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.


By Deborah Mitchell
BARCELONA, Spain (Reuters Health) Jul 09 - A single dose of nevirapine taken once or twice a week, or every other day, may act as a prophylaxis for HIV infection among individuals exposed to the virus through sexual or blood contact, a US team reported here at the XIV International AIDS Conference.

A two-dose course of nevirapine administered perinatally has proven effective in preventing vertical transmission of HIV to infants. This prompted Dr. J. Brooks Jackson and colleagues from Johns Hopkins University in Baltimore to undertake a phase I/II trial to investigate the efficacy of nevirapine prophylaxis among high-risk HIV-negative subjects.

In the HIVHOP 101 trial, a total of 33 high-risk HIV-negative subjects received one of three regimens for 12 weeks. Twelve patients received a 200-mg nevirapine tablet once weekly; 12 received 200-mg nevirapine tablets twice weekly; and nine took 200-mg nevirapine tablets every other day, Dr. Jackson told conference attendees. Eleven, eight, and five patients, respectively, completed the trial.

Sixteen of the 33 patients reported continued high-risk activity throughout the study, Dr. Jackson said. None of the 24 patients were HIV-positive at followup.

The subjects were also tested for toxicity and were followed by phone after 20 weeks. Although elevations in liver function enzymes were observed in each treatment group, and were highest in the every-other day group, no serious side effects were observed.

Dr. Jackson concluded that nevirapine prophylaxis is safe, as administered in these regimens over a 12-week period. However, he pointed out that caution is needed when administering nevirapine to patients with hepatitis B virus or other liver disease.

One possible application of nevirapine prophylaxis would be among commercial sex workers, Dr. Jackson suggested. For example, in some developing countries, women travel from rural to urban areas to work in the sex trade for limited periods of time and then return home. Therefore, nevirapine may provide a good short-term HIV prophylaxis for these women who have high HIV exposure for limited amounts of time.

"If the data hold up, and the safety looks good, perhaps nevirapine can be used for an extended period," Dr. Jackson added.



--------------------------------------------------------------------------------

[ Next Thread | Previous Thread | Next Message | Previous Message ]

[ Contact Forum Admin ]

Forum timezone: GMT-6
VF Version: 3.00b, ConfDB:
Before posting please read our privacy policy.
VoyForums(tm) is a Free Service from Voyager Info-Systems.
Copyright © 1998-2019 Voyager Info-Systems. All Rights Reserved.