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Date Posted: 19:12:43 07/24/02 Wed
Author: moonotter
Subject: Remune, Other Vaccines Prime Immune System Without IL-2

Remune, Other Vaccines Prime Immune System Without IL-2


Reuters Health Information 2002. © 2002 Reuters Ltd.
Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.


NEW YORK (Reuters Health) Jul 10 - A 38-patient study sponsored by the Adult AIDS Clinical Trials Group of the National Institutes of Health shows the patients developed stronger immune responses to HIV after receiving only Remune, an investigational therapeutic vaccine, than they did when they received Remune plus interleukin 2 (IL-2).
Dr. Hernan Valdez of the Case Western Reserve Center for AIDS Research presented the results of the study at the XIV International AIDS Conference in Barcelona, Spain. The Immune Response Corp. (IRC) developed Remune.

All patients in the study had been on regimen of highly active anti-retroviral therapy (HAART) or HAART plus IL-2 for at least 60 days, according to Immune Response. The 38 subjects were immunized with tetanus toxoid; inactivated, gp-120 depleted HIV-1 (Remune); and hepatitis A and B vaccines.

Even though investigators observed increased in CD4+ cell counts, the researchers concluded IL-2 did not enhance immunization responses. Patients receiving Remune alone developed relative stronger immune responses to HIV by a 70% to 24% margin, according to Immune Response.

The patients also experienced a stronger hepatitis A response after receiving the hepatitis A vaccine without IL-2. The group that received only the hepatitis A vaccine developed stronger hepatitis A antibodies (88%) compared to the group that received the vaccine plus IL-2 (36%).

"Non-specific stimulation via IL-2 may hinder the immune response to both Remune and non-HIV vaccines," said Ronald Moss, vice president of medical and scientific affairs for Immune Response, in a statement.

While Remune was once touted as a preventive vaccine, Immune Response is now positioning Remune as a treatment option in several scenarios, according to a company spokeswoman. The therapeutic vaccine may be appropriate as monotherapy to delay the start of HAART treatment, or it may be used in conjunction with HAART.

In May, however, Immune Response reported results of a new product that combines Remune and an adjuvant consisting of sequences of immunostimulatory DNA. The combination vaccine, which Immune Response is developing as a preventive vaccine, proved to be capable of boosting levels of HIV-specific T cells in non-human primates.



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