Re: if it's brown... -- world

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05/19/24 11:09:50pm

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Subject: Re: if it's brown...

Author:
pjk

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Date Posted: 11/14/05 3:41:52pm
In reply to: krz 's message, "Re: brownie anyone?" on 11/14/05 1:11:32pm

Good post krz-

>There is a difference between tamiflu and a vaccine.
>Tamiflu is only for after infection - vaccination is
>pre-infectious.

Good to know.

>There are other
>ways of creating vaccine - one that involves a version
>of cloning the RNA (viruses don't have DNA) of the
>virus. The turn around on that is much shorter - but
>the mechanism of innoculation is still a little shaky
>so the technology isn't used for predicted strains
>yet. An H5N1 pandemic might force researchers to test
>this mechanism before NIH might be 'ready' because
>it's the better option to doing nothing.

Hence, bioshield 2 to allow drug makers free reign to experiment on people without consequence due to worse case scenario?

>Tamiflu might help some people better than nothing at
>all. Every virus we know makes 3 different enzymes:
>one to get into the human cell, one to trigger the
>human cell DNA to replicate the virus RNA (a hostile
>take over as it were), and one to break out of the
>cell. Tamiflu blocks the enzyme neuraminidase which
>is the enzyme that lets the virus out of the cell. As
>such, the length, duration, and severity of the
>infection are seriously reduced -- but it doesn't keep
>you from getting infected in the first place.

Interesting!

>H5N1 kills people because of the human inflammatory
>response. Once the H5N1 virus gets out of human cells
>the cells themselves rupture and the human response to
>this is an inflammatory reaction. When this happens
>in the lungs or gut (prime sites for H5N1 infection)
>then human death comes from pneumonia like problems or
>profound dehydration.

Do you think that the few dozen victims were weak or had compromised immmune systmes? Or lack of decent care post-infection? What are the chances with a healthy person with great hospital care?

>H5N1 has me scared - much more so than SARS ever did.

Whatever happened to that one? And why just Toronto?

>Moral for now I guess - don't smoke, stay healthy, eat
>right, take extra C, exercise and keep your lungs in
>as tip top a shape as you can.... perhaps stock up on
>tamiflu. Quarrantine sick people - it's not the best
>solution, but better than any other way to halt a
>human-to-human spread.

Thanks doc.
P.S. I think I would love to take one of your classes!

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Replies:

Subject	Author	Date
Re: flush it down	Geo	11/15/05 9:18:06am
Re: flush it down -- krz, 11/15/05 11:11:01am
Re: if it's brown...	krz	11/15/05 11:09:43am