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05/19/24 3:51:49am

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Subject: Re: if it's brown... Author: krz [ Next Thread | Previous Thread | Next Message | Previous Message ] Date Posted: 11/15/05 11:09:43am In reply to: pjk 's message, "Re: if it's brown..." on 11/14/05 3:41:52pm >Good post krz- Thanks pjk - >Hence, bioshield 2 to allow drug makers free reign to >experiment on people without consequence due to worse >case scenario? No, actually this is really something that is still outside of the drug makers. The issue isn't the drug it's the immunization process. When infecting a human with dead virus or deactivated cloned virus the issue is in the dosage. Turns out we can innoculate with very little dead virus to get a great immune response -- the problem with cloned virus is in the amount you need to get the same response -- too much for a safe innoculation. So, at the moment, drug companies haven't spent much R&D here -- that might change with the threat of a pandemic. The issue for human testing is clearly much more of a problem with private drug companies who have their own institutional review boards and actually receive very little NIH money (thus little external oversight) than the work done at most universities. I think the challenge will be when NIH asks private industry to get involved because it's both right and profitable and then there is NIH type oversight as well. My limited experience with NIH is that they take human subjects protection pretty seriously. For a nice audio story link to the podcast: podcast@sciencefriday.com and look for the 11/4 podcast on the Federal Flu Plan. It's good listening if you're into that stuff. I get there through iTunes - don't know how else to get there (sorry, this might not have been much help). > >Do you think that the few dozen victims were weak or >had compromised immmune systmes? Or lack of decent >care post-infection? What are the chances with a >healthy person with great hospital care? Just a guess - nothing to back me up. I think it's a function of post-infection identification and health care. What's going to be important in the US is getting people who typically wait out a cold/flu to get into see the doc in the first 48. (you listening g?) That said, the immunocompromised and those with secondary conditions are going to be in much worse shape. Most deaths in the US will likely be folks who are not otherwise quite healthy. That said, it will take a few healthy ones too. I've read that the prediction is a 30% kill rate (compared to a 7-8%kill rate with SARS). > >>H5N1 has me scared - much more so than SARS ever did. > >Whatever happened to that one? And why just Toronto? Don't know - good question. > > >Thanks doc. >P.S. I think I would love to take one of your classes! thanks pjk [ Next Thread | Previous Thread | Next Message | Previous Message ]