The worst, seriously, it's Sam and Max: Hit the Road. It's VERY violent, the puzzles doesn't make sense, the cursor it's too big, and it's boring to play, it didn't got the little funny details like Zak, Monkey Island or Maniac Mansion, and the system of chosing a dialogue option is weird, this is the worst one, no doubt.
The sequel cancelled by LucasArts looked good, though.