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Date Posted: 21:08:48 01/15/07 Mon
Author: Vancomycin
Subject: Re: 醫藥問題~
In reply to: andy 's message, "醫藥問題~" on 01:39:59 01/15/07 Mon

>vanco你好~
>我想問點解nsaids 去引致胃痛,
>但paracetamol類既anagesic唔會既呢??
>咁我想問係咪類固純類既消炎藥就唔會引致胃痛??
>
>thanks for reply!


要知道點解就要少少physiology/pharmacology底

NSAID係COX inhibitor...COX(分COX-1同COX-2)負責製造唔同種類PG﹐其中PGE2其中一功能係負責保護胃部(黏膜生成+ HCO3-synthesis)﹐你NSAID係將所有好同壞PG都一併KO所以會引發胃痛/胃潰瘍

Paracetamol本身唔屬於COX system(但亦有科學家將佢分類做COX-3)﹐所以唔會KO 由普通COX生成既PG﹐paracetamol一般降熱同止痛功效比NSAID好但消炎功效較差。但過量服食會引致急性肝衰竭--->死亡。

如果要用NSAID但同時要止胃痛係有藥食(其實係補充返俾NSAID KO o左o既 PG)但一般情況係叫病人進食定時同用食物送藥﹐必要時可以轉藥試試。NSAID除左對胃部有刺激性外對腎同氣管都有影響。

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