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Date Posted: 07:29:08 05/02/02 Thu
Author: Junobear
Author Host/IP: 216-220-251-7.midmaine.com / 216.220.251.7
Subject: Welcome to the Hepatitis-C Treatment Casino. You're one of the lucky ones...
In reply to: Theresa 's message, "Ok got my genotype today soo" on 17:32:58 05/01/02 Wed

There are 2's and 3's who relapse or are non-responders -- but for the most part, 2's and 3's are able to treat half as long [24 weeks] for twice the sustained response rate [80%]. 80% is not 100% but it beats the hell out of rates for the 1's.

These are some of the factors that increase or decrease one's chances of sustained response:

1. Genotype 2 or 3 [the lucky genotypes];

2. low or very low pre-treatment viral load;

3. sex [higher SR rates for females];

4. weight [up the dose a bit if you're large or chubby];

5. pre-treatment condition of the liver [cirrhosis decreases one's chances of SR regardless of genotype -- cirrhotic 2's and 3's may want to consider treating longer than 24 weeks]; and

5. very early clearance of the virus on treatment [SR rates for those who go undetected the first 2-3 weeks of treatment are 95-98%].

Level of compliance with treatment also plays a major role. Drinking or drugging, skipping or delaying dosing because one is having a bad day, taking 'vacations' from treatment for special occasions, etc. all decrease one's chances of SR.

Welcome to the Hepatitis-C Treatment Casino. Plug in your profile and estimate your personal odds of sustained response...

...keeping in mind there are no guarentees for any of us. I know a couple of 2's and 3's with 'perfect profiles' for SR who relapsed. And, I also know a 1b with a 32 million pre-treatment viral load who is a sustained responder. The bottom line is, there is no way to know for sure except cast one's fate to the wind and try it.

Treatment sucks -- but its not as bad for 2's and 3's because: 1) some of us have the option of treating for 24 weeks instead of 48; and 2) knowing our odds are better keeps us hopeful and determined when side effects of treatment start to set in.

I treated 24 weeks in 98-99 and 'had it easy' compared to my friends the 1's.

This is good news.

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Replies:

[> [> Thank all of you for the input -- Theresa, 09:18:41 05/02/02 Thu (ppp35.mtholly.eticomm.net/208.9.146.35)

the more I learn the better I deal good or bad I would rather know what might be coming than plan on all good and get disappointed so I'll look at it this way I have a rather good genotype and good odds but there is always the chance that I will be an oddball lol
of course I really am an odd ball....


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[> [> [> Re: Thank all of you for the input -- sugarB, 10:14:17 05/02/02 Thu (02-142.067.popsite.net/64.24.73.142)

hi thresa, Im a 43 year old female , 3a and I had a 2 millon viral load when starting tx 6 months ago, I am now clear and doing 6 more months to try to get a sustained responce. I beleve very much that no matter how crappy I might feel on shot day I shoot anyway and work hard an not missing any riba pills .After all this 6 months of treatment I am very scared of relapsing so am determined to continue treatment as long as I can stand it. I wish you good luck , sugarB


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[> [> [> [> SugarB -- Susie, 15:41:41 05/02/02 Thu (bgp425870bgs.union01.nj.comcast.net/68.36.197.75)

I've heard that extending treatment doesn't really give you a better chance at sustaining your response. What did your doctor say about this?


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[> [> Hey Theresa I'm 3a as well,And I've heard nothing but good things about what we have we'll kick-it. -- Clarence, 02:37:59 05/03/02 Fri (d169.as0.rscm.mi.voyager.net/216.93.38.172)


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