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Date Posted: 21:32:44 03/05/04 Fri
Author: David I
Subject: Re: Texas A&M and DNA
In reply to: Melinda Proffer 's message, "Re: Texas A&M and DNA" on 18:17:07 03/03/04 Wed

I think we all need to remember that CHD is polygenic(many genes) and multifactorial(other environmental influences).

Using an outcross pedigree of greyhounds and dysplastic Labs researchers at Cornell have found one loci (group of genes) controlling hip laxity plus other markers. We all wish there were a single gene test but logically if you have a structure like a hip or a vagina for that matter any mutations affecting the entire structure will almost certainly involve many genes.

Would a genetic test replace xrays in CHD screening? I think it would be an adjunct to radiography, but not replace it. I think I have mentioned on this list pups response to hormones in mothers milk in relation to CHD. You can also take a mildly dysplastic pup and make it a grossly dyplastic adult just by mis(over)feeding it. We are interested not only in the genetic makeup of a dog but how those genes are expressed and once they are expressed how they react to the environment.

If you knew the absolute hip status of every Boerboel everyone would flock to Mr. and Mrs. Hips which would be a huge detriment to the breed as a whole from a population genetic standpoint. After all you are breeding dogs and not hips.

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